In the sterile industry, the competition between corrugated pipe valve and diaphragm has been lasted for a extended age. The diaphragm valve takes up the advantage since it is simple in structure, cheap in value and convenient in sterilization. Compared with this valve, the corrugated pipe valve has also hardly any specifications in the market. While, since Tuchenhagen Corporation produces the Vesta corrugated pipe valve, it fills the gap. Immediately the article will introduce the merits and demerits clearly through the comparison between the two valves.